Recently I’ve set up a Virtual PC, that is to say I’ve installed Microsoft Virtual PC 2007. I’m running it on Window Vista Home Premium, which is not actually a supported OS but it seems to work OK all the same:
I set up my “Virtual Machines” like this:
One base XP install with sp2
Then VS6 + Office XP(I didn’t have a copy of 2000 kicking around)
VS2005 + Office 2003
VS2008 + Office 2007

That’s it for the moment. Does this make sense? How do you have yours set up
The main thing I have noticed while using these VM’s is the use of memory/performance. I have a Centrino Duo ( T5500/1.6), Geforce Go 7600 and 2 gigs of Ram, Ok I’m running the VPC in Vista, but the maximum I can run any VM with is about 1.3 gigs, some times they run a bit slow, and I only really run one at a time.
I guess the performance hit is worth the isolation?